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在早产婴儿和新生儿的结果上层静脉流:一个系统的审查
Bishal Gautam1,2, Aimann Surak1,2, Sandra M Campbell3
1Department of Pediatrics, University of Alberta, Alberta, Canada.
American journal of perinatology
|June 20, 2023
概括
新生儿上腔静脉流量低 (SVC) 并不是不利结果的可靠预测指标. 目前的证据不足以支持其在早产婴儿的临床决策中使用.
科学领域:
- 新生儿生理学和血液动力学
- 在早产婴儿的临床结果.
- 系统审查方法论 系统审查方法论
背景情况:
- 上腔静脉 (SVC) 流动经常被用作新生儿系统血流的替代标记.
- 在新生儿早期低SVC流量的临床意义需要进一步调查.
研究的目的:
- 系统地审查新生儿早期低SVC流量与新生儿结局之间的关联.
- 评估SVC流动对早产婴儿不良临床结果的预测值.
主要方法:
- 在多个数据库 (PROSPERO,Medline,EMBASE,Cochrane等) 中进行系统的文献搜索. 在2022年10月之前.
- 包括11项研究 (九个队列),主要涉及怀孕30周以下的婴儿.
- 评估包括的研究是否存在偏差风险,并注意到显著的临床异质性和研究组的不可比较性.
主要成果:
- 有限的证据表明,SVC流量不是早产婴儿不良临床结果的独立预测因素.
- 包含的研究显示出高偏差风险,使得发现的解释变得复杂.
- 由于研究之间存在显著的临床异质性,因此没有进行元分析.
结论:
- 目前的证据不足以支持使用SVC流用于新生儿的预后或治疗决定.
- 在等待进一步的方法学强化研究之前,SVC流程解释应该仅限于研究环境.
- 需要改进的研究方法来准确评估SVC流在新生儿护理中的作用.
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