马疹病毒-1在跳跃比赛期间爆发:一项临床和流行病学研究
Anne Couroucé1, Camille Normand2, Caroline Tessier3
1BIOTARGEN UR7450, Université de Caen Normandie, Caen, France; RESPE, 3 rue Nelson Mandela, Saint Contest, France; ONIRIS, CISCO-ONIRIS, Route de Gachet, Nantes, Cedex, France.
Journal of equine veterinary science
|June 20, 2023
概括
马匹疹病毒-1 (EHV-1) 在一场马展的爆发导致了封锁. 雄性马和集中养的马对EHV-1感染和神经疾病的风险更高,这凸显了稳定的设计的重要性.
科学领域:
- 兽医流行病学 兽医流行病学
- 马类传染性疾病 马类传染性疾病
- 病毒病原体的产生
背景情况:
- 在CES瓦伦西亚春季巡回赛2021期间发生的马类疹病毒-1 (EHV-1) 疫情导致比赛取消和场地封锁.
- 专注于在场地剩余的160匹马的流行病学,临床,诊断和结果数据.
研究的目的:
- 描述疫情爆发期间受到EHV-1影响的马的流行病学,临床,诊断和结果特征.
- 确定与EHV-1感染和EHV-1髓脑病变 (EHM) 相关的风险因素.
主要方法:
- 追溯病例控制观察研究,分析60匹马的临床和定量聚合酶链反应 (qPCR) 数据.
- 后勤回归用于探索发展临床表现的风险.
- 通过qPCR检测EHV-1,基因定型 (A2254,ORF30) 和细胞培养分离.
主要成果:
- 在60匹马中,83.3%有发烧,50%没有其他症状,40%出现神经症状.
- 16%的人被住院治疗,死亡率为3%.
- 马和子感染EHV-1的可能性是马的6倍. 年龄大于9岁和住房中心位置增加了EHM风险.
结论:
- 男性的性别是EHV-1感染的风险因素,而年龄>9岁和中心稳定的位置是EHM的风险因素.
- 在EHV-1爆发期间,稳定的设计,位置和通风是至关重要的.
- 在疫情爆发期间,PCR测试对于有效管理隔离是必不可少的.
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