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在VLO中的5-HT_{7_{受体有助于在老鼠中发展吗啡诱导的行为敏感性}}

Jing-Si Yang¹, Fei-Fei Gao¹, Xi-Xi Yang¹

¹College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China; The Key Laboratory of Forensic Medicine (Xi'an Jiaotong University) of the National Health Commission, Xi'an, Shaanxi, 710061, China; Academy of Bio-evidence Science, Science and Technology Innovation Port in Western China, Xi'an Jiaotong University, Xi-Xian New District, Shaanxi, 710115, China.

Neurochemistry international

|June 20, 2023

概括

腹侧轨道皮层 (VLO) 中的5-西胺7受体 (5-HT7R) 在吗啡成中起作用. 在VLO中准5-HT7Rs和AKT酸化可能有助于管理吗啡诱导的行为敏感性.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

5-基胺7受体 (5-HT7R) 涉及各种生理和病理过程,包括药物成.
行为敏感化,以强化对重复药物暴露的反应为特征,是成的一个关键机制.
腹侧轨道皮层 (VLO) 已被确定为对吗啡强化作用至关重要.

研究的目的:

研究5-HT7Rs在VLO中对吗啡诱导的行为敏感化的作用.
探索涉及AKT酸化的潜在分子机制.

主要方法:

使用吗啡诱导行为敏感化.
选择性5-HT7R激活剂 (AS-19) 和抗剂 (SB-269970) 的微注射到VLO.
评估吗啡诱导的多动性.
测量AKT酸化 (p-AKT Ser 473) 的水平.

主要成果:

在VLO中激活5-HT7Rs增强了吗啡诱导的过活.
5-HT7Rs的对抗性抑制了急性吗啡过活和敏感化诱导,但没有表达.
吗啡诱导的行为敏感性与VLO中的p-AKT (Ser 473) 增加有关.
阻断敏感化诱导也阻止了p-AKT的增加.

结论:

在VLO中的5-HT7Rs有助于发展吗啡诱导的行为敏感性.
在VLO中的p-AKT信号参与了这种敏感化的分子机制.
准VLO 5-HT7Rs和p-AKT可能为管理吗啡成提供治疗策略.

关键词:

5-HT ((7) Rss 的使用情况.在 AKT AKT 里面.行为敏感化行为敏感化吗啡是一种吗啡.腹侧轨道皮层腹侧轨道皮层

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