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实时功能性磁共振成像神经反训练杏仁体的上调增加了抑郁症的情感灵活性

Laurie Compère¹, Greg J Siegle¹, Sair Lazzaro¹

¹From the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA (Compère, Siegle, Strege, Young); University of Pittsburgh Medical Center, Pittsburgh, PA (Lazzaro, Canovali, Barb); the Department of Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA (Huppert).

Journal of psychiatry & neuroscience : JPN

|June 20, 2023

概括

实时fMRI神经反针对主要抑郁障碍 (MDD) 中的杏仁体反应改善了症状并增加了情感灵活性. 这表明干预可以通过调节神经机制来增强情绪调节.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
临床心理学临床心理学

背景情况:

情感灵活性下降与抑郁症症状有关.
大型抑郁症 (MDD) 的干预措施可能针对情绪灵活性.
实时功能磁共振成像神经反 (rtfMRI-nf) 是调节神经活动的潜在工具.

研究的目的:

调查rtfMRI-nf培训是否可以在积极的记忆回忆过程中增加杏仁体反应,从而改善抑郁症状.
为了确定这种训练是否通过降低桃体对MDD患者认知任务的反应性来增强情感灵活性.

主要方法:

进行了一项双盲,安慰剂控制,随机的临床试验.
患有MDD的成年人接受了两次rtfMRI-nf,在积极的记忆回忆过程中准杏仁体 (实验) 或体 (对照) 反应.
在神经反和随后的计数任务中评估了杏仁体活动.

主要成果:

实验组显示杏仁体活动增加和抑郁症状减少 (d=1).
在神经反后的计数任务中,杏仁体活动下降 (d=0.48).
杏仁体反应性降低与抑郁症得分降低相关.

结论:

rtfMRI-nf可以改善抑郁症状,提高MDD患者的情感灵活性.
针对特定的神经机制可能导致情绪反应的双向控制.
研究结果支持情感灵活性在抑郁症治疗机制中的作用.

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