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免疫检查点抑制剂由于 pembrolizumab 引起的液状突发症

Benjamin Joseph McCormick¹, Daniel Zieman², Cassidy West-Santos³

¹Internal Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA mccormick.benjamin@mayo.edu.

BMJ case reports

|June 20, 2023

概括

作为免疫检查点抑制剂的 pembrolizumab 可以引起皮肤反应,如状突发症. 这项案例研究表明,高剂量的葡萄皮质激素有效地治疗了转移性膀癌患者的这些不良事件.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫疗法,如 pembrolizumab,是革命性的癌症治疗方法.
免疫相关不良事件 (IRAE) 是这些疗法的常见副作用.
尿生殖系统癌症,包括膀癌,用 pembrolizumab 治疗.

研究的目的:

报告皮肤免疫相关不良事件 (irAE) 的病例,其次是 pembrolizumab.
描述临床表现和管理状突发症.
为了突出转移性膀癌患者的治疗反应.

主要方法:

案例报告的呈现方式.
对临床表现和治疗过程的审查.
专注于癌症免疫治疗中的不良事件管理.

主要成果:

一名老年妇女在为转移性膀癌接受 pembrolizumab 治疗时出现了液状疹.
皮肤免疫相关不良事件 (irAE) 呈现为广泛的皮疹.
用高剂量的静脉注射葡萄糖皮质激素治疗导致了积极的临床反应.

结论:

皮肤IRAE是免疫检查点抑制剂的重要关注点,如pembrolizumab.
液状体喷发是这些IRAE的潜在表现.
用葡萄糖皮质激素进行及时和积极的治疗可以有效地管理这些皮肤学副作用.

关键词:

皮肤病学皮肤病学免疫学产品和疫苗.恶性疾病和免疫抑制医疗管理医疗管理不需要的副作用/不良反应.

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