在自闭症谱系障碍中使用第二代抗精神病药物:系统审查和元分析协议
Luis Phillipe Nagem Lopes1, Jardel Corrêa de Oliveira1,2, Cristiane de Cássia Bergamaschi1
1Pharmaceutical Science, University of Sorocaba, Sorocaba, Brazil.
BMJ open
|June 20, 2023
概括
本系统审查审查了治疗自闭症谱系障碍 (ASD) 的第二代抗精神病药物的有效性和安全性. 它综合了受控和观察性研究的证据,为治疗指南提供了信息.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 自闭症谱系障碍 (ASD) 影响全球数百万人,药物治疗的有效性有限.
- 非典型的抗精神病药物有时用于ASD,但对它们相对有效性和安全性的证据有限.
- 有控制和非控制的研究存在,需要进行全面的审查.
研究的目的:
- 系统地评估第二代抗精神病药物在被诊断为ASD的个体中的疗效和安全性.
- 为了比较随机对照试验 (RCT) 和观察性研究的结果.
- 为ASD药物治疗中的临床决策提供基于证据的见解.
主要方法:
- 系统性审查包括RCT和5岁以上自闭症患者的潜在队列.
- 在多个数据库 (Medline,Embase,PsycINFO等) 中进行搜索. 试验和试验的注册表.
- 使用RoB 2和ROBINS-I工具进行独立的数据提取和质量评估;潜在的元分析.
主要成果:
- 主要结局包括侵略性,生活质量和因不良事件而停止服用抗精神病药物.
- 二级结局侧重于非严重的不良事件和治疗坚持.
- 在必要时,证据综合将使用元分析和网络元分析.
结论:
- 这一综述将提供关于第二代ASD抗精神病药物的当前证据的全面总结.
- 结果将突出不同研究设计的有效性和安全性概况.
- 结果将通过出版物和演讲传播,以告知临床实践和未来的研究.
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