补充因子I基因变异作为复发性无菌性中性性脑膜炎的可治疗原因:一个病例报告
Mary Rolfes1, Adil Harroud1, Kelsey C Zorn1
1From the Weill Institute for Neurosciences (M.R., M.R.W.), Department of Neurology, University of California, San Francisco; Montreal Neurological Institute and Hospital (A.H.), Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Department of Biochemistry and Biophysics (K.C.Z., A.T.); Department of Laboratory Medicine (C.O., C.Y.C.); Kaiser Permanente Santa Rosa Medical Center (K.K.)Department of Medicine (M.M.), Division of Rheumatology; Department of Medicine (A.B.), Molecular Medicine Consult Service; Department of Medicine (C.Y.C.), Division of Infectious Diseases, University of California, San Francisco; The Peter Doherty Institute for Infection and Immunity (P.S.R.); Department of Neurology (P.S.R.), Royal Melbourne Hospital; and Department of Neurology (P.S.R.), St.Vincent's Hospital, University of Melbourne, Australia.
一个补充因子I (CFI) 基因变异,以前与神经问题无关,导致一个年轻人的脑膜炎复发. 用针对白蛋白-1β的canakinumab治疗导致缓解,这表明了新的治疗途径.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 神经学 神经学
背景情况:
- 复发性中枢神经系统 (CNS) 炎症可能与补充因子I (CFI) 基因突变有关.
- 补体系统在免疫反应和炎症调节中起着至关重要的作用.
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