早期生活压力,低度的全身炎症和在精神分裂症的面部处理过程中对默认模式网络 (DMN) 的抑制较弱
Sinead King1,2,3, David Mothersill1,4, Laurena Holleran1,3
1Centre for Neuroimaging, Cognition and Genomics (NICOG), University of Galway, Galway, Ireland.
Translational psychiatry
|June 20, 2023
概括
童年创伤与精神分裂症中大脑连接的改变有关,由炎症介导. 具体而言,童年忽视预测在任务期间通过升高的IL-6水平增加默认模式网络 (DMN) 连接.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 儿童创伤 (CT) 与精神分裂症的认知和社会认知功能受损有关.
- 现有研究表明,低级系统性炎症和默认模式网络 (DMN) 改变在静止状态期间调解了这种关系.
研究的目的:
- 调查儿童创伤是否会影响DMN在基于任务的活动中的连接性.
- 探索炎症和DMN连接在CT认知关系中的调解作用.
主要方法:
- 在社会认知面部处理任务期间使用fMRI扫描来测量DMN连接.
- 炎症标志物 (IL-6,IL-8,IL-10,TNFa,CRP) 的血水平使用ELISA量化.
- 参与者包括53名精神分裂症/精神分裂情绪障碍患者和176名来自iRELATE项目的健康对照.
主要成果:
- 精神分裂症患者表现出低度的全身炎症和增加的DMN连接 (LLP皮质-小脑,LLP-角性).
- 在所有参与者中,IL-6水平预测了几个区域 (LLP-小脑,LLP-前,mPFC-前中心/后中心旋转) 的DMN连接性增加.
- IL-6调解了童年身体疏忽与LLP-小脑连接之间的关联,疏忽得分也预测了IL-6/LLP-前链接.
结论:
- 这项研究是第一个在基于任务的活动期间儿童疏忽和DMN连接增加之间显示IL-6调解的研究.
- 这些发现支持了这样一个假设:创伤暴露与面部处理过程中改变的DMN抑制有关,这种抑制是由炎症介导的.
- 这些结果可能会阐明儿童创伤,炎症和精神分裂症认知缺陷之间的生物学机制.
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