高致病性岛屿和其他铁吸收系统之间的表观相互作用塑造了大肠杆菌 (Escherichia coli) 的肠外毒性
Guilhem Royer1,2,3,4,5, Olivier Clermont1, Julie Marin1,6
1Université Paris Cité, IAME, INSERM, Paris, France.
Nature communications
|June 20, 2023
概括
致病性大肠杆菌的毒性取决于特定的基因组合,而不仅仅是单个基因. 高致病性岛屿 (HPI) 和其他操作子,如aer或sit,以依赖于血统的方式为大肠杆菌的毒性作出贡献.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 肠外致病性大肠杆菌 (ExPEC) 毒性与各种基因有关.
- 这些毒性基因的具体贡献尚不清楚,并且取决于遗传背景.
研究的目的:
- 调查大肠杆菌中毒性的遗传基础.
- 了解特定基因组合的作用及其在ExPEC中的演变.
主要方法:
- 在232个STc58菌株和370个Escherichia菌株上进行全基因组关联研究 (GWAS).
- 在败血症小鼠模型中的病毒性量化.
主要成果:
- 在STc58菌株的一个子集中的毒性与高致病性岛屿 (HPI) 有关.
- 在更广泛的Escherichia菌株中,充分的毒性需要HPI加上aer或sit操作子.
- 这些操作子的存在,同时发生和位置是基因组学上依赖的.
结论:
- 在大肠杆菌中病毒性的出现是由病毒性基因的血统特定关联所塑造的.
- 强烈的表皮性相互作用影响了ExPEC毒性的演变.
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