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肠道微生物群Turicibacter菌株对胆酸和宿主脂质进行差异性修改

Jonathan B Lynch^1,2, Erika L Gonzalez³, Kayli Choy³

¹Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jlynch48@jhmi.edu.

Nature communications

|June 20, 2023

概括

肠道细菌修改胆汁酸,影响宿主脂肪的新陈代谢. 特定的Turicibacter基因使这些细菌能够改变宿主胆酸概况,影响脂质水平和体重.

科学领域:

微生物学微生物学
肠道微生物组研究研究
主体与微生物的相互作用

背景情况:

图里西巴克特菌在哺乳动物肠道中很常见,与饮食和体重有关.
杜里西巴克特 (Turicibacter) 影响宿主生理学的确切机制尚不清楚.

研究的目的:

调查Turicibacter分离物在胆酸代谢中的功能作用.
为了确定负责宿主脂质代谢中Turicibacter介导的改变的特定基因.

主要方法:

多种小鼠和人类Turicibacter分离物的表征.
对胆汁酸转化和胆汁盐酸酶活性进行分析.
殖民化实验用 gnotobiotic 小鼠和工程细菌.

主要成果:

图里西巴克特的分离物表现出特定菌株的胆酸修饰能力.
与Turicibacter的殖民化在体内改变了宿主胆酸特征.
图里西巴克特胆汁酸修饰基因的表达降低了宿主胆固醇,甘油三和脂肪组织.

结论:

图里西巴克特菌株拥有基因,使其能够修改宿主胆酸.
这些修改影响宿主脂质代谢和脂肪生物学.
图里西巴克特是宿主脂肪代谢的显著调节者.

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