白质中的结构功能合揭示了精神分裂症中异常的大脑连接.
Jiajia Zhao1, Chu-Chung Huang2,3, Yajuan Zhang4
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Translational psychiatry
|June 20, 2023
概括
精神分裂症患者表现出白质 (WM) 结构-功能合的减少,表明神经元信息传输受损. 这种WM通道的功能障碍与症状严重程度和疾病持续时间相关,支持失联性假设.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症的特征是失联综合征,有结构和功能整合受损的证据.
- 白质 (WM) 微结构异常在精神分裂症中经常被报告,但WM功能障碍及其与功能之间的关系尚不清楚.
研究的目的:
- 开发和验证WM中结构功能合的新型测量方法,以评估神经元信息传输.
- 研究与健康志愿者 (HV) 相比,精神分裂症 (SZ) 患者的白质结构和功能之间的关联.
主要方法:
- 利用了来自75 SZ和89 HV的功能和扩散磁共振成像 (MRI) 数据.
- 开发了一种新的度量法,将时空功能信号相关性与WM电路中的扩散张力定向相结合.
- 在HV组验证了结构-功能合测量,以评估神经信号传输能力.
主要成果:
- 与健康志愿者相比,精神分裂症患者的WM结构-功能合性普遍下降.
- 受影响的WM区域包括皮质脊髓管和上纵囊.
- 在WM通道中结构功能合的减少与精神病症状严重程度和疾病持续时间有显著的相关性.
结论:
- 在WM通道中异常的神经元信号传输,通过减少结构-功能合量化,可能是精神分裂症的关键神经病理机制.
- 这项研究通过突出WM网络中的电路功能受损,支持了精神分裂症的失联性假设.
- 白质网络在精神分裂症的病理生理学中发挥着关键作用.
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