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转质氨酶2的表达与淋巴结转移的风险增加和乳头甲状腺癌的复发有关
Yagmur Goksoy Solak1, Gulcin Yegen2, Semen Onder2
1Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. yagmurgoksoy@gmail.com.
Endocrine
|June 20, 2023
概括
在初级瘤中转质氨酶2 (TG2) 染色预测了乳头甲状腺癌中的淋巴结转移. 较高的TG2分数与转移风险增加相关,为患者的随访和治疗策略提供了信息.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 转氨酶2 (TG2) 涉及到瘤细胞的动员,入侵和化学抵抗.
- 了解TG2在乳头甲状腺癌 (PTC) 进展中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 调查TG2的免疫组织化学染色与乳头甲状腺癌患者的转移状态之间的关联.
- 为了确定TG2表达水平是否在转移性和非转移性PTC之间有所不同.
主要方法:
- 分析了76名PTC患者,根据转移分类 (没有,只有淋巴结,远 ±淋巴结).
- 评估了使用免疫组织化学在原发性瘤和瘤外组织中的TG2抗体染色.
- 根据原发性瘤TG2染色,将患者分为高风险 (TG2评分≥3) 和低风险 (TG2评分<3) 类别.
主要成果:
- 高TG2染色 (A组) 与增加的血管入侵,甲状腺囊入侵,甲状腺外延伸,甲状腺内传播,淋巴结转移和侵略性组织学显著相关.
- 两组之间没有观察到远程转移的显著差异.
- 每增加1个点的TG2染色得分与淋巴结转移风险增加1.9倍相关.
结论:
- 主要瘤的TG2染色得分可以作为PTC中淋巴结转移的预测生物标志物.
- TG2表达水平可能会影响PTC患者的随访频率和治疗决策.
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