血红蛋白与败血症患者28天死亡率的相关性:使用MIMIC-IV数据库进行二次数据挖掘
Yu Chen1, Lu Chen2, Zengping Meng1
1Clinical Laboratory Center, The Affiliated Hospital of Guizhou Medical University, 28, Guiyi Street, Guiyang, Guizhou, China.
BMC infectious diseases
|June 20, 2023
概括
血红蛋白水平显示出U形的关联与败血症患者的28天死亡率. 较低的血红蛋白 (41-104 g/L) 降低了死亡风险,而较高的血红蛋白 (128-207 g/L) 增加了死亡风险.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 血红蛋白水平与败血症患者的死亡率之间的关联仍然存在争议.
- 之前的研究对这种联系产生了相互矛盾的结果.
研究的目的:
- 为了研究出血红蛋白基线与败血症患者28天死亡率之间的关系.
- 使用医学重症监护IV (MIMIC-IV) 数据库进行分析.
主要方法:
- 从MIMIC-IV数据库 (2008-2019) 中,对34916名败血症患者进行了回顾性队列研究.
- 血红蛋白是暴露变量;28天死亡率是结果.
- 经过调整,包括人口统计,并发病 (查尔森指数),SOFA分数,生命体征和药物等混因素.
- 分析了使用二进制逻辑回归和两部分线性模型的关联.
主要成果:
- 在血红蛋白水平和28天死亡率之间观察到非线性U形关系.
- 血红蛋白水平在41-104 g/L之间与28天死亡风险降低10%有关 (OR:0.90;95% CI:0.87-0.94).
- 血红蛋白水平在128-207g/L之间显示,每单位增加的28天死亡风险增加了7% (OR:1.07;95%CI:1.01-1.15).
- 在104-128g/L血红蛋白与死亡率之间没有发现显著的关联.
结论:
- 基线血红蛋白水平显示出U形的关联与败血症患者的28天死亡率.
- 低血红蛋白水平和高血红蛋白水平都可能与败血症死亡风险增加有关.
- 进一步的研究可能会探索这些发现对败血症管理的临床影响.
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