双相情绪障碍中不同情绪发作的荷尔蒙和炎症特征:一项大型临床研究
Nan Lyu1, Qian Zhao1, Bingbing Fu1
1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
BMC psychiatry
|June 20, 2023
概括
周围激素的特征可以区分躁狂和抑郁情节在双相情感障碍 (BD). 综合性激素,压力激素和CRP水平为BD患者的情绪状态提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 标志着严重的情绪波动.
- 荷尔蒙失衡与 BD 情绪波动有关.
- 周围激素配置文件区分躁狂和抑郁情节的能力尚不清楚.
研究的目的:
- 调查BD中不同情绪情节的外周激素和炎症标志物变化.
- 为了确定BD的情绪情节特定的外围生物标志物.
- 评估生物标志物的歧视潜力,以区分躁狂和抑郁症发作.
主要方法:
- 对8332名BD患者的分析 (2679名抑郁,5653名躁狂发作).
- 测量血清丸激素,雌激醇,孕,上腺皮质激素 (ACTH),皮质醇和C反应蛋白 (CRP).
- 使用的接收器操作特征 (ROC) 曲线分析用于生物标志物歧视.
主要成果:
- 躁狂发作显示较高的丸激素,雌激素,孕激素和CRP,与抑郁发作相比,ACTH较低.
- 经过对混因素进行调整后,,ACTH和CRP水平仍然是显著的差异化因素.
- 综合生物标志物显示出性别和年龄特异性的影响,特别是在45岁以上的男性中 (AUC=0.70).
结论:
- 激素和炎症变化独立地与BD情绪发作有关.
- 结合性激素,压力激素和CRP可以提高躁狂和抑郁症之间的区别.
- 研究结果表明,BD中存在特定于性别和年龄的生物特征,支持有针对性的干预措施.
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