在受多囊性卵巢综合征影响的情况下引入一种最佳的卵巢刺激方法:随机对照试验
Azar Yahyaei1, Samira Vesali2, Firouzeh Ghaffari3
1Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
BMC women's health
|June 20, 2023
概括
通过尿道人类绝经性淋巴激素 (u-HMG) 进行最小的卵巢刺激 (OS) 似乎是多囊性卵巢综合征 (PCOS) 的女性体外受精 (IVF) 的最佳方案. 这种方法平衡了卵细胞产量,妊娠率,并降低了OHSS风险.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 妇科内分泌学内分泌学
背景情况:
- 在患有多囊性卵巢综合征 (PCOS) 的患者中进行体外受精 (IVF) 的最佳卵巢刺激 (OS) 协议仍未确定.
- 结核复合症是一种常见的内分泌疾病,影响女性生育能力,需要量身定制的试管婴儿方法.
研究的目的:
- 评估最小的OS策略对接受试管婴儿的PCOS不育患者的有效性.
- 为了比较复合FSH (r-FSH) 与尿液HMG (u-HMG) 在使用GnRH-对手的最小和轻度OS协议中的影响.
主要方法:
- 一项随机对照试验,涉及120名符合条件的PCOS患者接受试管婴儿.
- 患者被分为四组:最小或轻度的OS,具有r-FSH或u-HMG.
- 试管婴儿的结果被统计分析,以比较这四组.
主要成果:
- 在不同组的刺激持续时间,卵细胞产量和胚胎数量中观察到显著的差异 (p < 0.0001).
- 在受精率或植入率上没有显著差异.
- 临床怀孕和活产率差异很大,使用u-HMG的最小OS显示出有希望的结果. 通过完全结周期来预防OHSS也存在显著差异 (p = 0.004).
结论:
- 使用u-HMG的最小OS可能是接受试管婴儿的PCOS患者的最佳方法.
- 该方案在雌激素水平,淋巴激素剂量,卵细胞/胚胎产量,临床怀孕率和降低OHSS风险方面表现出有利的结果.
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