荷兰非结核性菌根性肺病患者的现实治疗模式,基于药物发行数据
W Hoefsloot1, E Dacheva2, R van der Laan3
1Radboudumc Center for Infectious Diseases, Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, Netherlands. Wouter.Hoefsloot@radboudumc.nl.
BMC pulmonary medicine
|June 20, 2023
概括
非结核性菌根性肺病 (NTM-LD) 的真实世界抗生素管理表明患者遵守,但经常改变治疗和早期停止. 改善NTM-LD护理需要更好的准则遵守和专家中心参与.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 非结核性菌根性肺病 (NTM-LD) 的治疗是复杂的,全球现实数据有限.
- 了解当前的抗生素管理实践对于优化患者治疗结果至关重要.
研究的目的:
- 为了评估荷兰NTM-LD的真实世界抗生素治疗实践.
- 分析使用分发数据的治疗方案,持续性,切换,合规性和重新启动.
主要方法:
- 使用荷兰大型药品发行数据库 (IQVIA) 进行了回顾性纵向研究.
- 包括2015年10月至2020年9月期间开始接受NTM-LD治疗的患者.
- 研究的初始治疗方案,治疗持久性,药物持有率 (MPR) 和治疗重新开始.
主要成果:
- 465名患者开始接受双重或三重药物NTM-LD治疗.
- 三重药物治疗的平均MPR为90%,但治疗时间的中位数为119天.
- 47%和20%的患者分别在6个月和1年后继续接受治疗,18%的患者在停止治疗后重新开始治疗.
结论:
- 患者在接受NTM-LD治疗时表现出良好的遵守性,但过早停止和治疗切换是常见的.
- 很大一部分患者需要在间隔后重新开始治疗.
- 加强NTM-LD管理需要提高准则的遵守和专家中心的合作.
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