COVID-19初级免疫接种和强剂疫苗接种方案的反应性和安全性:一个比较的观察队列研究
Lisette Warkentin1, Felix Werner2, Nikoletta Zeschick2
1Institute of General Practice, Friedrich-Alexander-Universität Erlangen-Nürnberg, Uniklinikum Erlangen, Universitätsstraße 29, Erlangen, Germany. lisette.warkentin@uk-erlangen.de.
BMC medicine
|June 20, 2023
概括
在比较COVID-19疫苗方案时,BNT162b2显示出最低的反应性,特别是在同源计划中. 然而,反应性很少导致所有方案的医疗咨询,没有发现增加的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 针对COVID-19疫苗接种活动的动态建议需要混合疫苗方案的数据.
- 关于异种 (混合) COVID-19 疫苗计划的安全性和有效性的数据有限.
- 评估常见的COVID-19疫苗方案的感知反应性和医疗咨询需求至关重要.
研究的目的:
- 为了比较同源和异源COVID-19疫苗接种方案的感知反应性.
- 评估在不同的COVID-19疫苗接种计划之后需要医疗咨询的需要.
- 分析COVID-19疫苗接种的短期和长期安全结果.
主要方法:
- 一项观察性队列研究,涉及17,269名参与者.
- 基于网络的调查评估了反应性 (短期) 和医疗服务利用率 (长期).
- 随访时间延长至接种疫苗后124天.
主要成果:
- BNT162b2表现出最低的反应性,特别是在同源疗法中;mRNA-1273显示出最高的局部反应.
- 系统反应最常见的是异的ChAdOx1-mRNA-1273和同的mRNA-1273/mRNA-1273疗法.
- 所有方案的医疗咨询率都相当,反应性很少导致医生访问或住院护理.
结论:
- 在COVID-19疫苗和方案之间存在反应性差异,BNT162b2通常表现出较低的反应性.
- 反应性很少导致医疗咨询,无论使用的疫苗接种方案.
- 在随访期间,没有任何COVID-19疫苗接种方案与寻求医疗咨询的风险显著增加有关.
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