子周长与糖尿病之间的关联:系统性审查和元分析
Dandan Li1, Yuxin Zhao2, Lifang Zhang3
1Department of Medical Records Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. 1536721300@qq.com.
Diabetology & metabolic syndrome
|June 20, 2023
概括
子周长是糖尿病风险的重要预测指标. 增加子周长与患2型糖尿病和妊娠期糖尿病的风险更高有关,即使考虑到BMI.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 子周长 (NC) 越来越被认为是代谢功能障碍的潜在指标.
- 之前关于NC和糖尿病风险之间的关联的研究已经产生了有争议的结果.
- 需要对现有证据进行定量综合,以澄清这种关系.
研究的目的:
- 量化评估子周长 (NC) 与患糖尿病 (DM) 的风险之间的关联.
- 为研究NC作为DM风险因素的观察性研究提供全面的元分析.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行了系统的文献搜索,截至2022年9月.
- 包括观察性研究来检查NC和DM风险之间的联系.
- 采用随机效应模型的元分析,从16项选定的研究中汇集了数据.
主要成果:
- 分析包括16项研究,包括4764名DM患者和26159名参与者.
- 升高的NC显着与2型DM (T2DM) (OR=2.17) 和妊娠DM (GDM) (OR=1.31) 的风险增加有关.
- 在调整BMI (OR=1.94) 之后,NC和T2DM之间的关联仍然显著,NC每厘米增加1.16 OR.
结论:
- 这些发现提供了强有力的流行病学证据,将更大的子周长与T2DM和GDM风险增加联系起来.
- 子周长作为评估糖尿病风险的有价值,非侵入性人体测量标记.
- 进一步的研究可能会探索NC在DM查和预防策略中的临床实用性.
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