在莫桑比克的消毒性患者中,分子检测Helicobacter pylori及其基因型抗菌耐药性模式
Muhammad Ismail1, Nashon D Majaliwa2,3,4, Filipa F Vale4,5
1Department of Gastroenterology, Hospital Central de Maputo, Maputo, Mozambique.
Helicobacter
|June 20, 2023
概括
在莫桑比克患有消化不良的患者中,Helicobacter pylori感染很常见. 对甲基和基诺的高耐药率需要持续监测和适应疗法,以有效根除.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 遗传学 遗传学 是一个
背景情况:
- 杆菌表现出显著的基因型多样性,病原性和耐药性与特定的基因有关.
- 关于莫桑比克的H. pylori抗生素耐药性模式的数据有限.
- 了解局部耐药性对于有效的H. pylori根除策略至关重要.
研究的目的:
- 为了确定H. pylori在莫桑比克消化不良患者中的患病率.
- 为了调查基因型对克拉里胺素,甲尼达和诺基诺的耐药性.
- 以基于局部耐药率的临床治疗决策为基础.
主要方法:
- 横截面描述性研究 (2017年6月至2020年6月) 涉及171名消化不良患者.
- 通过上部胃肠内镜检查获得的胃活检.
- 聚合酶链反应 (PCR) 和基因测序 (23S rRNA,rdxA,gyrA) 以检测H. pylori和耐药性突变.
主要成果:
- 在56.1% (96/171) 的患者中检测到H. pylori.
- 抗生素耐药性率:克拉里胺10.4% (A2142G,A2143G突变),美特罗尼达55.2% (D59N,R90K,H97T,A118T突变,经常结合),诺20% (N87I,D91G突变).
- 针对每个抗生素耐药性的特定突变.
结论:
- 在莫桑比克的消毒症患者中,H. pylori感染很普遍.
- 观察到对甲化醇和诺基诺的显著耐药性.
- 持续监测抗生素耐药性和适应性治疗对于根除H. pylori是必不可少的.
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