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在CT成像,病理和肺部地面玻璃不透明性的基因型之间的相关性探索

Yong Cai¹, Tong Chen², Shiju Zhang²

¹Department of Radiation Oncology, Shanghai Tianyou Hospital, Shanghai, China.

Journal of cellular and molecular medicine

|June 21, 2023

概括

地玻璃不透明 (GGO) 结节通常发生在年轻的,非吸烟妇女中,可以表明恶性病变. 像真空标志和腔痕这样的成像标志表明恶性病,而EGFR突变在侵入性腺癌中很常见,指导个性化治疗.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

在高分辨率计算机断层扫描 (HRCT) 上越来越多地检测到地面玻璃不透明 (GGO) 结节.
了解GGO的临床,成像,病理和分子特征对于诊断和治疗至关重要.
这项研究调查了单个GGO病变,以建立最佳的管理策略.

研究的目的:

分析经过手术治疗的GGO结节的临床特征,成像发现,病理类型和遗传检测结果.
探索GGO患者的有效诊断和治疗方案.
为建立标准化GGO处理过程提供基础.

主要方法:

通过HRCT和病理学证实单个GGO病变的465名患者的回顾性分析.
临床,成像,病理和分子生物学数据的统计研究.
随着时间的推移,对患者进行随访,观察GGO的变化.

主要成果:

恶性GGO (432例) 与良性GGO (33例) 在尺寸,真空体标志,多叶内和血管标志方面有显著差异.
在61.2%的腺癌样本中发现了EGFR突变,在微侵袭性腺癌 (mGGO) 和侵袭性腺癌中检测率高.
随访期间GGO生长和固体成分的出现表明恶性瘤和需要手术切除.

结论:

GGO主要影响年轻的,非吸烟女性,其大小和特定的成像征兆与恶性瘤相关.
EGFR突变在恶性转基因中普遍存在,特别是侵入性腺癌,支持向治疗.
GGO表现出异质性,需要基于全面分析的个性化诊断和治疗计划.

关键词:

电脑计算的X射线成像地面玻璃的不透明度 (GGO)肺部/病理学肺部/病理学瘤基因的基因基因.扫描断层扫描 (tomography) 是一个非常重要的技术.

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