在小儿心肺绕道手术后,血-抗血复合体和急性损伤之间的关联:单中心回顾性观察性研究
Sakura Minami1,2, Hiroyuki Nagafuchi1, Kaori Yamada1
1Department of Critical Care Medicine, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan.
概括
在接受心肺旁路心脏手术的儿童中,在早期的儿科重症监护室停留期间,高血-抗血复合物 (TAT) 水平与急性损伤 (AKI) 发病有关.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 进行心血管外科手术.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血管内皮损伤可以引发高凝血,可能导致急性损伤 (AKI).
- 早期检测凝血变化对于治疗儿科心血管外科手术中术后并发症至关重要.
研究的目的:
- 调查早期凝血变化与心肺绕道术 (CPB) 后儿科患者AKI发病之间的关联.
主要方法:
- 一个单一中心的回顾性队列研究,涉及154名婴儿和幼儿接受了CPB心血管手术.
- 在儿科重症监护室入院时测量绝对血-抗血复合物 (TAT) 水平.
- 在早期术后期观察AKI发病的情况.
主要成果:
- 55%的参与者 (35%) 发展了AKI.
- 在幼儿中,较高的绝对TAT水平与AKI发病有显著的相关性 (几率比,4.70;P = .023).
结论:
- 在CPB手术后的幼儿中,TAT绝对水平的增加与AKI早期发病有关.
- 需要进一步的前性多中心研究来验证这些研究结果在更大的儿科患者群体.
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