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溶酶体和血积累性和瘤向性聚烯纳米颗粒用于增强的声动疗法

E Pang¹, Xuejian Xing¹, Shaojing Zhao¹

¹Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China. minhuanlan@csu.edu.cn.

Journal of materials chemistry. B

|June 21, 2023

概括

这项研究引入了一种基于聚乙烯的新型声敏化剂 (PT2) 用于声动疗法 (SDT). 这些纳米粒子有效地向癌细胞,诱导细胞死亡,并在超声波照射下消耗瘤,为深层瘤提供了有希望的新疗法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

声动力疗法 (SDT) 显示出对固体瘤的承诺,这是由于深层组织的透和非侵入性.
现有的超声敏剂在超声波稳定性和耐药性方面存在局限性.
需要新的材料来提高SDT的有效性和安全性.

研究的目的:

开发和评估一种基于聚乙烯衍生物的新型声敏化剂 (PT2),用于声动疗法.
评估PT2载荷纳米粒子 (PDPFNP) 的生物相容性,向癌细胞的能力和治疗效果.
在超声波照射下研究PDPFNP的作用机制和瘤耗尽能力.

主要方法:

一种聚二烯衍生物 (PT2) 与四级盐和十二链的合成.
将PT2封装成用叶酸功能化的聚乙烯糖醇纳米颗粒 (PDPFNP).
在超声波 (US) 照射下PDPFNP的生物相容性,细胞吸收,反应性氧物种生成和抗瘤作用的体外和体内评估.

主要成果:

在癌细胞 (溶解体和血膜) 中,PDPF NPs 显示出出色的生物相容性和有针对性的积累.
在美国照射下,PDPFNP产生单片氧和超氧化离子,诱导癌细胞亡和亡.
在体内研究显示,在美国治疗PDPFNP后,显著的瘤抑制和耗尽.

结论:

聚乙烯衍生物可以作为SDT的有效音响敏感剂.
与传统的超声敏剂相比,PDPF NPs提供了增强的超声波稳定性和治疗效果.
这种新的方法有可能通过声动疗来改善深层固体瘤的治疗.

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