瘤微环境通过新辅助埃洛提尼布疗法调节及其对可操作EGFR突变非小细胞肺癌的临床影响
Beung-Chul Ahn1, Charny Park2, Moon Soo Kim3
1Center for Lung Cancer, Division of Hematology and Oncology, Department of Internal Medicine, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Cancer research and treatment
|June 21, 2023
概括
新辅助埃洛提尼布治疗 (NE) 影响EGFR突变非小细胞肺癌 (NSCLC) 的瘤微环境 (TME). 免疫通路的激活与 NE 治疗的 NSCLC 患者的更好的反应和生存相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 皮肤上生长因子受体 (EGFR) 氨酸激酶抑制剂 (TKI) 改善了EGFR突变 (EGFRm) 非小细胞肺癌 (NSCLC) 的存活率.
- 新辅助埃洛提尼布治疗 (NE) 对可手术EGFRmNSCLC瘤微环境 (TME) 的影响在很大程度上是未知的.
- 了解NE对TME调制的理解对于优化治疗策略至关重要.
研究的目的:
- 评估新辅助埃洛提尼布治疗 (NE) 在可操作EGFR突变非小细胞肺癌 (NSCLC) 的瘤微环境 (TME) 中引起的变化.
- 调查基线TME特征与对NE的治疗反应之间的相关性.
主要方法:
- 一个单臂II期试验,涉及II/IIIA阶段EGFRm NSCLC患者,接受多达2个周期的NE.
- 通过对切除的瘤组织进行基因表达分析和突变分析来评估TME变化.
- 患者接受了基于NE反应的辅助疗法.
主要成果:
- 在25名患者中,NE的客观反应率为72%.
- 基因组丰富分析揭示了中白素,补充剂,细胞因子,转化生长因子β和刺后NE. hedgehog路径的上调.
- 病原体防御,白内素和T细胞功能通路的基线上调与部分反应和更长的整体存活 (OS) 有关.
- 细胞循环通路在基线上升调与稳定/进展性疾病和较短的生存期相关.
结论:
- 新辅助埃洛提尼布疗法 (NE) 在EGFR突变非小细胞肺癌 (NSCLC) 中有效调节瘤微环境 (TME).
- 在TME中,免疫相关途径的升级与改善的临床结果有关,包括反应和生存.
- 基线免疫状态影响患者对NE的反应,这表明预测生物标志物的潜力.
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