基于变的多重测试对P<注释>$$ P $$-值和对集群随机试验的置信区间进行了校正
Samuel I Watson1, Joshua O Akinyemi2, Karla Hemming1
1Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Statistics in medicine
|June 21, 2023
概括
本研究介绍了多个结果的集群随机试验中P值校正和置信区间的方法. 罗马诺-沃尔夫程序为治疗效果估计提供了更好的错误控制和效率.
科学领域:
- 生物统计学 生物统计学
- 临床试验 临床试验
- 统计推理 统计推理
背景情况:
- 具有多个结果的集群随机试验 (CRT) 对统计推理提出了挑战.
- 现有的P值校正和置信区间构造方法在这个设置中是有限的.
研究的目的:
- 在具有多个结果的CRT中推导和比较P值校正和置信区间的方法.
- 确保对家庭智能错误率的强有力的控制和治疗效果估计的覆盖.
主要方法:
- 调整了邦费罗尼,霍尔姆和罗曼诺-沃尔夫的方法,用于使用换测试进行CRT推断.
- 开发了一种新的搜索程序,通过变换测试来确定信任度设置极限.
- 进行模拟研究,比较使用基于模型和排列测试的错误率,覆盖率和效率.
主要成果:
- 罗马诺-沃尔夫类程序显示了名义错误率和覆盖范围,即使有非独立的相关性.
- 这种方法比模拟研究中的其他方法更有效.
- 结果与现实世界的试验分析进行了验证.
结论:
- 罗马诺-沃尔夫程序是一种强大的,高效的方法,用于CRT的统计推理,具有多个结果.
- 在这种复杂的设置中,开发的基于换的方法增强了P值校正和置信区间的构建.
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