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基于菌素的抗微生物预防的有效性,用于跨直肠超声波引导的前列腺活检:一项韩国多中心研究

Do Gyeong Lim¹, Seung Il Jung², Eu Chang Hwang¹

¹Department of Urology, Chonnam National University Medical School, Gwangju, Korea.

Investigative and clinical urology

|June 21, 2023

概括

结合诺基诺 (FQ) 和菌素 (FM) 抗生素,可显著减少通过直肠超声波引导前列腺活检 (TRUSPB) 后的感染性并发症. 医疗保健的使用被确定为这些活检后感染的关键风险因素.

科学领域:

传染性疾病传染性疾病
泌尿器科泌尿器科泌尿器科泌尿器科
药理学药理学是指药理学的学科.

背景情况:

通过直肠超声导向前列腺活检 (TRUSPB) 后感染并发症的增加与耐诺 (FQ) 生物体有关.
抗生素预防对于预防这些感染至关重要,但耐药性模式需要评估替代策略.

研究的目的:

调查基于菌素 (FM) 的抗生素预防是否可以减少 TRUSPB 后的感染.
确定导致TRUSPB后感染并发症的独立风险因素.

主要方法:

在韩国 (2018-2021) 进行的一项多中心研究包括2595名接受前列腺活检的患者.
患者接受了FQ单疗法 (第一组),FM单疗法 (第二组) 或FQ和FM联合预防 (第三组).
分析了传染性并发症率和风险因素.

主要成果:

总体而言,活检后感染并发症的发生率为1.27%.
感染性并发症的发病率为2.4% (FQ),1.9% (FM) 和0.5% (FQ+FM),组合疗法显示显著较低的发病率 (p=0.002).
在多变量分析中,医疗保健利用率 (aOR 4.66) 和联合预防 (aOR 0.26) 是显著的预测因素.

结论:

与诺基诺和福米辛的联合抗生素预防在减少TRUSPB后的传染性并发症方面表现出比单一治疗更高的疗效.
医疗保健的利用已成为活检后传染性并发症的独立风险因素.

关键词:

活检是为了检查生物质.化类类类.斯福米辛是一种菌素.感染感染感染前列腺前列腺前列腺

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