调节肝脏的草药化合物的作用,通过恢复荷尔蒙和精子细胞的亡,对静脉相关的丸功能障碍的影响
Guorong Jin1, Jianrong Liu2, Caiyun Ding3
1Central Laboratory, Shanxi Provincial People's Hospital, Affiliate of Shanxi Medical University, Taiyuan 030012, China. guorongjin@163.com.
Urology journal
|June 21, 2023
概括
肝调节性草药化合物 (LRHC) 通过调节激素和减少细胞亡来改善瘤诱导不孕症的精液质量. 这种传统中医疗方法为男性不孕症的治疗提供了潜在的治疗方法.
科学领域:
- 生殖生物学 生殖生物学
- 安德罗学与人类学
- 传统中国医药 传统中国医药
背景情况:
- 静脉是男性不孕症的一个重要原因.
- 静脉切除术并不总是恢复生育能力,需要使用替代治疗方法.
- 传统中医药,特别是肝调节草药化合物 (LRHC),在患有静脉的不育患者中改善精液质量和生育能力方面表现有前途.
研究的目的:
- 阐明LRHC在解决瘤相关的男性不孕症方面的潜在机制.
- 为了研究LRHC对激素平衡和精子细胞亡的作用,在一个静脉鼠模型中.
主要方法:
- 在老鼠中诱导了静脉,随后进行90天的LRHC.胃内注射.
- 使用ELISA评估了荷尔蒙水平.
- 精子细胞亡和基因表达被通过西式涂抹和流动细胞计分析.
主要成果:
- LRHC治疗使发泡激素刺激激素 (FSH) 水平升高的发泡激素诱导的老鼠正常化.
- 在丸组织和塞尔托利细胞中,LRHC上调FSH受体 (FSHR) 表达.
- 通过调节Bax和Bcl-2表达,LRHC增强了细胞活力,并通过调节Bax和Bcl-2表达,保护了精子细胞免受低氧诱导的亡.
结论:
- LRHC证明了对 varicocele 诱导的精子发生障碍的保护作用.
- 通过调节荷尔蒙平衡和减轻精子细胞亡,特别是在低氧条件下,LRHC的功能.
- 这些发现支持LRHC作为一种潜在的治疗策略,用于治疗瘤相关的男性不孕症.
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