在COVID-19大流行期间,川崎病发病率和表型的变化
Ayse Mine Ünlü1,2, Mette Holm2, Thomas Krusenstjerna-Hafstrøm2
1Department of Rheumatology, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg.
Danish medical journal
|June 21, 2023
概括
川崎病 (KD) 的发病率和表现在COVID-19大流行期间发生了变化. 在大流行期间,KD患者表现出IVIG抗性的增加,但没有冠状动脉扩张.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 川崎病 (KD) 的病因不明,但可疑是传染性触发因素.
- 由于COVID-19流行病的感染预防措施可能改变了KD发病率.
- 这项研究调查了大流行期间丹麦的KD变化.
研究的目的:
- 在COVID-19大流行之前和期间评估川崎病 (KD) 的发病率.
- 分析KD表型的变化和疫情期间的KD结果.
- 评估流行病相关变化对KD患者特征的影响.
主要方法:
- 丹麦KD患者的回顾性队列研究 (2008-2021年).
- 在COVID-19大流行期间诊断的KD病例与大流行前的KD病例的比较.
- 对临床标准,治疗反应和冠状动脉干扰的分析.
主要成果:
- 在大流行期间发现了10例KD病例;所有病例都是SARS-CoV-2阴性.
- 疫情初期,KD发病率达到顶峰,随后的12个月内没有任何病例.
- 流行性冠状动脉疾病患者表现出更高的IVIG抗性 (60%vs.28.3%) 和没有冠状动脉扩张 (0%vs21.9%).
结论:
- 川崎病 (KD) 发病率和表型在COVID-19大流行期间发生了变化.
- 流行病时代的KD患者呈现出完整的疾病,肝酶升高和显著的IVIG耐药性.
- 重要的是,在疫情期间诊断的KD患者中没有观察到冠状动脉干扰.
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