检查男性老龄化时丸激素和生物标志物之间的关联
Stephen J Smith1,2, Daniel Bekele3, Adrian L Lopresti1,2
1Clinical Research Australia, Perth, Western Australia, Australia.
概括
肥胖和2型糖尿病 (T2DM) 标志物独立地与男性较低的总 (TT) 和性激素结合型球蛋白 (SHBG) 相关. 这项大型研究强调了慢性疾病对老龄化男性激素水平的影响.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 代谢疾病 代谢疾病
背景情况:
- 在老年男性中,丸激素度自然下降.
- 这种与年龄相关的衰退的确切原因仍然不完全理解.
- 慢性疾病如肥胖和2型糖尿病 (T2DM) 可能会影响水平.
研究的目的:
- 调查肥胖和T2DM与总 (TT) 和性激素结合球蛋白 (SHBG) 之间的关联.
- 利用一个庞大的,具有全国代表性的数据集 (国家健康和营养检查调查;NHANES) 进行可靠的分析.
主要方法:
- 分析来自NHANES 2013-2014年和2015-2016年调查的横截面数据.
- 包括18岁及以上的男性参与者.
- 评估身体质量指数 (BMI),口服葡萄糖耐受性测试 (OGTT),HOMA-IR,胰岛素,葡萄糖和年龄.
主要成果:
- 超重/肥胖 (BMI) 显示与TT和SHBG有显著的反向关联.
- T2DM标志物 (OGTT,胰岛素,HOMA-IR) 与TT相反相关;在调整后,OGTT和胰岛素仍然显著.
- 年龄与TT相反相关,与SHBG相反,独立于其他变量.
结论:
- 肥胖标志物 (BMI) 和T2DM标志物独立且显著与较低的TT和SHBG相关.
- 研究结果表明,慢性疾病在老年男性的丸激素水平调节中起着至关重要的作用.
- 这项研究提供了迄今为止检查这些关联的最大数据集.
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