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在肺炎中与假牙相关的细菌组内的组成变化 - - 一项分析横截面研究
Joshua A Twigg1,2, Ann Smith3, Clotilde Haury1
1School of Dentistry, Cardiff University, Wales, UK.
Journal of medical microbiology
|June 21, 2023
概括
假牙表面可以容纳呼吸道病原体,增加老年人肺炎的风险. 这项研究发现,与健康对照人群相比,假牙佩戴者患有肺炎的病原体水平显著更高.
科学领域:
- 微生物学 微生物学
- 老年学是指老年学的学科.
- 牙科的生物材料
背景情况:
- 细菌性肺炎是老年人疾病和死亡的主要原因.
- 许多老年人戴着可拆卸的假牙,通常由聚甲基甲酸制成.
- 口腔细菌可以转移到呼吸道,可能导致肺炎.
研究的目的:
- 调查假牙表面是否可以作为呼吸道病原体的殖民点.
- 为了比较口腔细菌社区在假牙佩戴者和没有肺炎.
主要方法:
- 一项分析横截面研究将35名没有呼吸道感染的脆弱老年人与26名住院肺炎患者进行了比较.
- 通过16S rRNA元taxonomic测序确定了细菌群体的组成.
- 定量PCR特别检测到肺炎性链球菌.
主要成果:
- 患有肺炎的牙套佩戴者显示,假定呼吸道病原体的丰度在统计学上显著,增加了20倍以上 (P<0.0001).
- 在肺炎患者的假牙微生物群中观察到细菌多样性 (Chao指数,P=0.0003) 和丰富性 (反向辛普森指数,P<0.0001) 的显著变化.
- 假牙相关的细菌群落在肺炎患者和健康对照人群之间有显著差异.
结论:
- 牙膏烯酸材料可能充当呼吸道病原体的殖民点,可能增加易感个体的肺炎风险.
- 这些发现支持了之前的观察性研究,该研究将假牙使用与呼吸道感染风险增加联系起来.
- 需要进一步的研究来确定假牙殖民,转移和肺炎之间的因果关系.
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