在奥米克朗时代的COVID-19相关的分泌性耳中炎:一个病例系列
Yu Zhang1, Jingrui Liu1, Feifei Yang1
1Department of Otolaryngology, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) RNA被检测到中耳液的患者与分泌性中耳炎,即使鼻检测是负面的. 这表明病毒可以在中耳感染后持续存在.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 在SARS-CoV-2 Omicron变种流行后观察到分泌性耳中炎 (SOM) 病例的增加.
- 在SARS-CoV-2 Omicron感染和SOM之间的直接联系仍然不清楚.
研究的目的:
- 为了调查SOM.患者的中耳溢液 (MEE) 中存在SARS-CoV-2的存在.
- 探索SARS-CoV-2感染和SOM的发展之间的关系.
主要方法:
- 对30名患有SOM和疑似SARS-CoV-2感染的患者进行了小时膜切开.
- 使用逆转录-聚合酶链反应 (RT-PCR) 对SARS-CoV-2 RNA分析了中耳溢液和鼻分泌物.
主要成果:
- 在30名患者中,有5名患者的MEE中检测到SARS-CoV-2RNA.
- 一名患者在鼻分泌物和MEE两方面都有阳性SARS-CoV-2结果.
- 分析了六名患者的医疗记录 (五名MEE阳性,一名MEE阴性).
结论:
- 与COVID-19相关的SOM.患者的中耳液中可能存在SARS-CoV-2RNA.
- 在MEE中检测SARS-CoV-2RNA是可能的,即使有负面的鼻PCR测试.
- 在SARS-CoV-2感染后,病毒可能在中耳液中长时间存在.
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