在患有良性基本血栓的患者中,非运动性表现和运动障碍之间的关系
Yemeng Zhou1,2,3, Wushuang Wang1,2,3, Zhirong Lin4
1Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
概括
良性基本血栓 (BEB) 患有眼睛干燥,情绪或睡眠问题的患者会出现更严重的运动症状. 对运动症状的肉毒神经毒素治疗也改善了BEB患者的干眼和睡眠障碍.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 良性基本血栓 (BEB) 是一种神经运动障碍.
- 在BEB患者中,干眼,情绪障碍和睡眠障碍等非运动性表现很常见.
- 在BEB中运动和非运动症状之间的关系以及治疗对这些症状的影响需要进一步研究.
研究的目的:
- 研究BEB患者的非运动症状 (眼睛干燥,情绪障碍,睡眠障碍) 和运动障碍严重程度之间的关联.
- 确定用于治疗运动症状的肉毒神经毒素治疗是否可以缓解BEB的非运动症状.
主要方法:
- 一项前性案例系列研究包括123名BEB患者.
- 运动严重程度使用詹科维奇评分表 (JRS) 和白发作残疾指数 (BSDI) 进行评估.
- 使用眼表面疾病指数 (OSDI),希尔默测试,撕裂分解时间 (TBUT),撕裂半径高度,脂层厚度 (LLT),角膜光染色,Zung的自我评价焦虑和抑郁量表 (SAS,SDS) 和匹兹堡睡眠质量指数 (PSQI) 来评估非运动症状.
主要成果:
- 与没有干眼或情绪障碍的BEB患者相比,BEB患者的JRS得分较高.
- 睡眠障碍患者的BSDI值较高.
- 在运动严重程度尺度 (JRS,BSDI) 和非运动症状评估 (SAS,SDS,PSQI,OSDI,TBUT) 之间观察到显著的相关性.
- 肉毒神经毒素治疗有效降低了JRS和BSDI得分,并在治疗后一个月改善了PSQI,OSDI,TBUT和LLT.
结论:
- 干眼,情绪障碍和睡眠障碍等非运动性表现与BEB中更严重的运动症状有关.
- 运动症状的严重程度与非运动症状的严重程度相关.
- 在BEB患者中治疗运动症状的肉毒神经毒素治疗在改善相关干眼和睡眠障碍方面表现出有效性.
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