聚乙烯甘醇-b-聚--烯-罗拉克) 纳米颗粒作为一个平台,以改善可纳比迪奥的口服输送

相关实验视频

Updated: Jul 26, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Inbar Shreiber-Livne^1,2,3, Liron Sulimani^4,5, Anna Shapira²

¹Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion - Israel Institute of Technology, Technion City, Haifa, 320003, Israel.

Drug delivery and translational research

|June 21, 2023

概括

这项研究开发了新的纳米颗粒,以增强大麻 (CBD) 的口服输送. 与自由CBD相比,封装CBD在老鼠中显示出更好的生物可用性和更快的吸收,提供了一个有前途的纳米技术解决方案.

科学领域:

纳米技术纳米技术
药品制造业药品制造业药品制造业
材料科学材料科学材料科学

背景情况:

大麻二醇 (CBD) 具有治疗潜力,但由于水溶性较低,其口服生物利用性较差.
现有的配方经常面临有效性和潜在不良影响的挑战.

研究的目的:

为了研究CBD在poly (乙烯基醇) -b-poly (epsilon-caprolactone) 纳米颗粒中的封装.
评估含有CBD的纳米颗粒的物理化学特性,释放特征和口服药理动力学.

主要方法:

纳米粒子合成的纳米沉方法.
高性能液体染色学 (HPLC) 用于封装效率和加载.
动态光散射 (DLS),SEM和冷TEM用于表征.
在模拟的胃和肠道条件下进行体外释放研究.
在老鼠体内药理动力学研究.

主要成果:

实现了~100%的封装效率和11%的CBD w/w加载.
生产的单分散纳米粒子 (<100nm) 具有球形形态,没有CBD晶体.
已证明依赖pH的释放:10%在pH1.2 (1h) 和80%在pH6.8 (2h) 时.
在体内研究显示,与自由CBD相比,Cmax增加了约20倍,AUC增加了14倍,Tmax降低了 (0.3h与4h).

结论:

开发的纳米技术战略显著提高了CBD的口服性能.
这些纳米颗粒提供了一种可扩展和可重复的方法来提高CBD生物可用性,而不是传统配方.
这些发现支持这些纳米颗粒在有效的CBD口服药物输送方面的潜力.

关键词:

大麻二醇 (CBD) 是一种口服纳米药物输送方式口服药物动力学口服药物动力学聚乙烯-乙烯) 是一种聚乙烯-乙烯-乙烯化合物.聚合物纳米颗粒的材料.

更多相关视频

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

相关概念视频

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.