通过汗水吸收两种不同硫化矿物质的矿物质的生物可访问性
Carla Marina Bastos1,2, Fernando Rocha3, Carla Patinha3
1Department of Geosciences, GeoBioTec Research Centre, University of Aveiro, 3810-193, Aveiro, Portugal. mbastos@exatronic.pt.
Environmental geochemistry and health
|June 21, 2023
概括
皮套安全需要对潜在的风险和有益元素进行测试. 这项研究开发了一种分析元素行为和皮肤相互作用的方法,在模拟出汗过程中发现有毒元素的低溶性.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 在热疗法中使用皮洛伊德需要对配方和物质释放进行安全评估.
- 了解基本益处对于解释皮肤治疗在皮肤和骨肌疾病中的有效性至关重要.
研究的目的:
- 开发一种方法来评估在配制的皮质体中元素的生物地质化学行为.
- 评估与皮质使用相关的安全性和潜在的皮肤暴露风险.
主要方法:
- 使用本托尼特粘土和不同的硫酸矿物药用水,制备两个皮质.
- 应用稳定的人工汗水测试来模拟皮肤相互作用.
- 使用感应合等离子体质谱法 (ICP-MS) 分析了31个提取的元素.
主要成果:
- 潜在的有毒元素和金属在模拟出汗过程中具有非常低的溶解度和无法检测的数量.
- 分析方法提供了可靠的皮肤暴露数据.
- 能够识别出具有系统循环潜力的元素.
结论:
- 开发的分析方法对于评估皮质安全性和皮肤暴露是有效的.
- 对于被确定为可能进入系统循环的元素,建议采取监督和控制措施.
- 进一步研究皮质体的治疗益处和元素相互作用是有必要的.
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