在CKD人群中扩大Gliflozin覆盖范围的预算影响分析:法国观点
Gérard de Pouvourville1, Patrick Rossignol2,3, Meriem Boussahoua4
1ESSEC Business School, Cergy Pontoise, France.
Advances in therapy
|June 21, 2023
概括
格利弗洛辛通过减缓慢性病 (CKD) 的进展和减少并发症,为法国医疗保健系统提供了显著的5年成本节省. 这种针对慢性病患者的新疗法,无论患有糖尿病,都具有成本效益.
科学领域:
- 药物经济学 药物经济学
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
背景情况:
- 最初用于2型糖尿病的gliflozin现在在法国推用于心力衰竭和慢性病 (CKD).
- 高级卫生当局最近的建议支持在这些新适应症中使用gliflozin.
- 慢性脏病影响着大量的人口,这对医疗保健来说是一个重大挑战.
研究的目的:
- 评估在法国引入gliflozins对CKD患者的5年预算影响.
- 从法国医疗保健系统的角度评估经济影响.
- 分析与标准治疗相关的成本与gliflozin添加相比.
主要方法:
- 使用DAPA-CKD试验数据开发了一个预算影响模型.
- 考虑了直接的医疗成本,包括药物采购,不良事件,透析,移植和临床结果.
- 市场份额预测和事件率基于历史数据,专家意见和试验数据.
主要成果:
- 预计Gliflozin的引入将节省成本,累计5年预算影响为-650亿欧元.
- 慢慢慢性病进展减少了末期病病例 (84,526 vs 92,062).
- 由于心力衰竭 (-14.3亿欧元) 和脏相关护理 (-894亿欧元) 的住院减少,观察到显著的成本补偿.
结论:
- 将gliflozin的指示扩展到法国CKD患者群体中,可以大大减少心脏脏并发症负担.
- 在CKD中使用gliflozin的好处超过了额外的治疗成本.
- 早期诊断和主动管理,与gliflozin治疗一起,是缓解CKD经济和临床影响的关键.
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