心脏 Amyloidosis 的门疾病:一个心声谱得分
Alberto Aimo1,2, Iacopo Fabiani3, Agnese Maccarana4
1Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy. a.aimo@santannapisa.it.
The international journal of cardiovascular imaging
|June 21, 2023
概括
心脏粉症 (CA) 显著影响心脏门. 与轻链CA (AL-CA) 相比,粉样性跨素CA (ATTR-CA) 显示出明显的中枢异常,这表明诊断的特定得分.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 心脏病理学心脏病理学
背景情况:
- 心脏粉症 (CA) 可以影响所有心脏结构,包括心脏门.
- 在患者管理中,区分粉样性跨氨酸CA (ATTR-CA) 和轻链CA (AL-CA) 是至关重要的.
- 心声谱在诊断和表征心脏病的过程中起着关键作用.
研究的目的:
- 调查ATTR-CA和AL-CA之间的门参与的回声心脏学差异.
- 开发和验证一个用于识别ATTR-CA的门评分系统.
- 评估门得分在患有不明原因心脏缩的患者中的有用性.
主要方法:
- 对423名接受CA治疗的患者进行了回顾性分析.
- 选择了20名患者,每个人都有ATTR-CA,AL-CA和匹配的对照.
- 对31个门相关项目的详细心声评估,为异常分配分数.
主要成果:
- 与AL-CA患者相比,ATTR-CA患者表现出更频繁的缩短/隐藏的后部 mitrale 叶片,加厚的 mitrale chordae tendineae,以及大动脉狭窄.
- 与对照组相比,ATTR-CA患者的后部额叶叶片化发生的频率较低.
- 门得分显示ATTR-CA和AL-CA (15.8对11.0,p=0.004) 之间以及ATTR-CA与其对照组 (p=0.009) 之间存在显著差异.
- 门得分达到0.782的曲线下的面积,用于诊断ATTR-CA.
结论:
- ATTR-CA与突出的中枢结构和功能损伤有关.
- 一个新的心声回声评分可以帮助区分ATTR-CA和AL-CA.
- 这种门分数可能有助于在患有CA或不明原因心脏缩的患者中识别ATTR-CA.
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