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复发的急性淋巴细胞白血病复发

Jasmeet Sidhu^1,2,3, Manash Pratim Gogoi², Shekhar Krishnan^1,2,4

¹Department of Pediatric Hematology and Oncology, Tata Medical Center, Kolkata, 700160, India.

Indian journal of pediatrics

|June 21, 2023

概括

儿童急性淋巴细胞白血病 (ALL) 的结果有所改善,但复发的ALL仍然是一个重大的挑战,稳定生存率. 新的免疫疗法,细胞疗法和精确瘤学策略对于改善复发ALL的结果至关重要.

科学领域:

儿科瘤学儿科瘤学
血液学血液学血液学
癌症治疗方法癌症治疗方法

背景情况:

在全球范围内,儿童急性淋巴细胞白血病 (ALL) 的生存率超过85%.
复发ALL的结果仍然很差,约为50%,对儿童癌症死亡率作出了重大贡献.
18个月内早期的骨髓复发预示着一个特别糟糕的预后.

研究的目的:

突出治疗复发性急性淋巴细胞白血病 (ALL) 的持续挑战.
强调需要对复发和药物耐药性机制有更好的生物学理解.
讨论在复发性ALL治疗中整合新型治疗选择和精确瘤学策略.

主要方法:

审查当前的治疗支柱:化疗,放射治疗和造血干细胞移植 (HSCT).
探索新兴的治疗方案,包括免疫疗法和细胞疗法,用于复发ALL.
讨论针对个性化治疗策略的综合精确瘤学方法.

主要成果:

尽管ALL治疗总体有所改善,但复发病例的结果并没有显著改善.
新的策略,如免疫疗法和细胞疗法提供了潜在的改善结果.
精密瘤学越来越多地被用于为个别患者量身定制治疗,特别是那些患有耐火性疾病的患者.

结论:

对ALL复发和药物耐药性进行增强的生物学洞察力至关重要.
创新的治疗策略和全球合作对于改善复发ALL的存活率至关重要.
了解新型疗法和精准医学的最佳应用对于推进复发性ALL的护理至关重要.

关键词:

化疗化疗是一种化学疗法.童年所有的童年复发复发的情况移植移植移植移植

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