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建立基于五种与饥饿相关的长非编码RNA的预后模型,用于清细胞细胞癌

Zhou Yu^1,2, Guo Chen^1,3, Zhenwei Feng^1,3

¹Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

|June 21, 2023

概括

饥饿通过改变长非编码RNAs (lncRNAs) 影响清细胞细胞癌 (ccRCC). 特定的lncRNAs如LINC-PINT,AC108449.2和AC007637.1具有预后价值,可以为ccRCC患者提供临床决策.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

饥饿诱导的瘤微环境会改变遗传特征,包括长非编码RNA (lncRNAs).
这些遗传变化调节恶性行为,如清细胞细胞癌 (ccRCC) 的入侵和迁移.

研究的目的:

研究ccRCC中与饥饿相关的lncRNAs (SR-LncRs) 的临床意义.
开发基于SR-LncRs的ccRCC患者的预后风险评分模型.

主要方法:

分析了来自539个ccRCC瘤和72个正常组织的TCGA转录组数据.
在患者样本上进行了体外实验 (qPCR,迁移,入侵测定).
开发了一个与饥饿相关的风险评分模型 (SRSM),使用关键的lncRNAs.

主要成果:

确定了170个SR-LncRs,其中25个与ccRCC患者的存活率有关.
通过使用LINC-PINT,AC108449.2,AC009120.2,AC008702.2和AC007637.1.1构建了一个SRSM.
LINC-PINT过度表达与预后差和晚期相关,而AC108449.2和AC007637.1显示了相反的趋势和与等级的相关性.

结论:

在预测ccRCC预后方面,LINC-PINT,AC108449.2和AC007637.1具有临床意义.
这些lncRNA与各种临床参数相关,有助于风险分层.
开发的SRSM为ccRCC的临床决策提供了有价值的工具.

关键词:

清细胞细胞癌是什么?在cnRNA中.风险评分模型的风险评分模型.饥饿饥饿饥饿饥饿饥饿

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