来自Euphorbia atoto的两种新的抗炎特拉基兰二甲
Huan Zhao1,2, Rui-Jun Duan1,3, Chui-Hao Kong2
1Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Journal of Asian natural products research
|June 21, 2023
概括
从Euphorbia atoto中分离出了两种新的特拉基洛巴尼euphoratones,以及五种已知的diterpenoids. 一些化合物在初步测试中表现出微弱的抗炎作用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学是指药理学,它是指药理学.
- 药用化学 医学化学
背景情况:
- 欧类物种是多样化类的丰富来源.
- 特拉基洛巴尼euphoratones代表了一类具有潜在生物活性的化合物.
研究的目的:
- 从Euphorbia atoto.中分离和描述新的和已知的二类植物.
- 为了评估分离的化合物的抗炎潜力.
主要方法:
- 使用色谱技术分离化合物.
- 通过高分辨率电喷射电离质谱法 (HRESIMS) 和核磁共振 (NMR) 光谱法阐明结构.
- 在体外抗炎活性测定.
主要成果:
- 发现了两种新的特拉基洛巴尼euphoratones,即Euphorbones A-B. 这两种新型的特拉基洛巴尼euphoratones被发现.
- 另外,还分离和描述了五种已知的四平类动物.
- 化合物1,3,4和7表现出较弱的抗炎活性,IC50值在16.00~77.49μM之间.
结论:
- 对Euphorbia atoto的化学研究产生了新的和已知的二类植物.
- 孤立的化合物,特别是欧骨A-B,需要进一步研究它们的抗炎性质.
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