经过支气管肺功能障碍之后,呼吸道阻塞在一生中不断增加:一个元分析
James T D Gibbons1,2,3, Christopher W Course4, Emily E Evans5
1Children's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth, Australia.
ERJ open research
|June 21, 2023
概括
过早分娩的幸存者表现出呼吸道阻塞的增加,特别是那些患有支气管肺功能障碍症的人. 随着年龄的增长,肺功能下降,这表明阻塞随着时间的推移而恶化.
科学领域:
- 肺部医学 肺部医学
- 新生儿科学 新生儿科学
- 流行病学 流行病学
背景情况:
- 关于早产幸存者的肺功能轨迹的研究有限.
- 越来越多的证据表明,在一些早产的个体中,呼吸道阻塞逐渐发生.
- 这项研究提供了关于早产对呼吸道阻塞的影响的首次元分析.
研究的目的:
- 对早产对呼吸道阻塞的影响进行元分析.
- 在早产幸存者中调查1秒内强制呼吸量 (FEV1) 与强制生命能力 (FVC) 的比率.
- 为了检查支气管肺功能障碍 (BPD) 和年龄对肺功能的影响.
主要方法:
- 包括报告FEV1/FVC在早产 (<37周怀孕) 和按期出生的个体中的队列.
- 使用随机效应模型 (标准化平均差异,SMD) 进行了元分析.
- 进行了元回归,以年龄和出生年份为调节者.
主要成果:
- 55个队伍有资格;35个定义的BPD组.
- 预产期幸存者的FEV1/FVC (SMD -0.56) 低于预产期对照组.
- 患有BPD的个体比没有 (SMD -0.45) 的个体显示出更大的阻塞 (SMD -0.87).
- 年龄显著预测BPD病例的FEV1/FVC下降 (-0.04每年SDS).
结论:
- 过早分娩的幸存者表现出明显增加的呼吸道阻塞,相比于满期出生的个人.
- 患有BPD的个人经历更明显的呼吸道阻塞.
- 肺功能 (FEV1/FVC) 随着年龄的增长而下降,这表明整个生命过程中呼吸道的逐渐阻塞.
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