一个COVID+患者的腹腔穿孔病例,患者接受了托西利祖马布和皮质类固醇治疗
Bilal Chaudhry1, Kirill Alekseyev2, Lidiya Didenko2
1Christiana Care Health System, Newark, DE, USA.
托西利祖马布可能会增加COVID-19患者腹腔穿孔的风险,特别是在与类固醇结合时. 类固醇可以掩盖症状,使得诊断这种严重并发症更加困难.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致严重的肺炎.
- 几种治疗方法已被批准用于严重的COVID-19,包括托西利祖马布和皮质类固醇.
- 胃肠道参与COVID-19是一个公认的现象.
研究的目的:
- 在接受托西利祖马布和类固醇治疗的COVID-19患者中报告腹腔穿孔病例.
- 探索在COVID-19中将托西利祖马布,类固醇和腹腔穿孔联系在一起的潜在机制.
- 在这种情况下,要突出类固醇使用带来的诊断挑战.
主要方法:
- 一名62岁的男性因COVID-19肺炎住院的病例报告.
- 对患者治疗方案的审查,包括甲基前尼索隆,雷梅西维尔和托西利祖马布.
- 对可能导致腹腔穿孔的潜在因素的分析.
主要成果:
- 患者在接受甲基前尼索隆,雷梅西维尔和托西利祖马布治疗后出现腹腔穿孔.
- 穿孔的拟议机制包括胃肠道中ACE-2受体的存在,类固醇诱导的免疫抑制以及托西利祖马布的不良影响.
- 类固醇可以抑制腹腔穿孔的临床症状.
结论:
- 托西利祖马布,特别是与类固醇结合使用,可能会增加COVID-19患者腹腔穿孔的风险.
- 类固醇的抗炎作用可以掩盖腹部并发症的关键症状.
- 需要对这种潜在的不良事件进行进一步调查.
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