相关实验视频
Updated: Jul 26, 2025

06:30
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
237
Telitacicept用于自身免疫性病的治疗方法
Jingjing Cai1, Dan Gao1,2,3,4, Dongwei Liu1,2,3,4
1Department of Integrated Traditional and Western Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in immunology
|June 21, 2023
概括
泰利塔西针对B细胞存活因子BAFF和APRIL,这些因子在自身免疫性疾病中至关重要. 本综述涵盖了它的机制,临床数据,以及在治疗自身免疫性病如狼性炎中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- B细胞和幽默免疫是自身免疫性疾病发病的核心.
- B细胞存活因子B细胞激活因子 (BAFF) 和诱导增殖的配体 (APRIL) 对于B细胞的维护和功能至关重要.
- 过度表达BAFF/APRIL与自身免疫性疾病有关,包括类风湿性关节炎,全身性红斑狼和IgA脏病.
研究的目的:
- 审查Telitacicept的作用机制和临床数据,这是一种针对BAFF和APRIL的新型TACI-Fc融合蛋白.
- 讨论自身免疫性病的免疫特征,重点关注狼性炎,IgA病和膜性病.
主要方法:
- 对Telitacicept,BAFF,APRIL和自身免疫性病的现有文献的综述.
- 对Telitacicept与BAFF和APRIL的结合特性进行分析.
- 对Telitacicept在全身性红斑狼和其他自身免疫性疾病中的临床试验数据的检查.
主要成果:
- 泰利塔西塞普有效地结合和中和BAFF和APRIL.
- 泰利塔西塞普在中国被批准用于治疗全身性红斑狼.
- 目前正在进行对Telitacicept在各种自身免疫征兆的临床试验.
结论:
- 泰利塔西通过向关键B细胞生存途径,代表了一种有前途的治疗策略.
- 该药物对全身性红斑狼的疗效表明,它对其他自身免疫性疾病,特别是自身免疫性病有潜在的益处.
- 对Telitacicept在狼性炎,IgA病和膜性病中的作用进行进一步研究是有必要的.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
177
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
177
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
202
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
202
Nephrotic Syndrome II : Assessment and Medical Management
10
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
10
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Nephrotic Syndrome I : Introduction
10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
10
Autoimmune Disorders
527
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
527

