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相关概念视频

Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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相关实验视频

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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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干细胞的秘密细胞传递系统

Abd Kakhar Umar1,2

  • 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Advanced pharmaceutical bulletin
|June 21, 2023
PubMed
概括
此摘要是机器生成的。

干细胞分泌体具有治疗潜力,但需要先进的输送系统. 优化的剂量形式和设备提高了稳定性,向性输送和各种器官治疗的疗效.

关键词:
无细胞疗法是一种无细胞疗法.秘密一些交付系统.干细胞的秘密是干细胞的秘密.

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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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科学领域:

  • 再生医学是一种再生医学.
  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统

背景情况:

  • 干细胞分泌体含有治疗性生物分子.
  • 秘密体的直接使用受到体内不稳定性和降解的限制.
  • 局部化和稳定传递系统的进步对于治疗疗效至关重要.

研究的目的:

  • 讨论临床障碍和潜在的解决方案,以提供秘密体.
  • 描述各种秘密传递系统和相关设备.
  • 探索最佳策略,用于治疗应用中的秘密传递.

主要方法:

  • 审查现有的关于秘密基因传递系统的文献.
  • 分析影响秘密体保留和释放的物理化学性质 (例如,孔隙性,颗粒大小,粘性弹性).
  • 检查不同剂型 (水凝,支架,涂层) 和施用装置 (喷雾器,吸入器,植入物) 的检查.

主要成果:

  • 各种输送系统,如水凝,支架和生物模拟涂层,可以稳定和维持秘密释放.
  • 输送系统的物理化学性质显著影响了秘密的质量,数量和治疗疗效.
  • 对于不同的器官和输送途径,需要特定的输送策略 (例如,吸入时冷化,血脑屏障时冷化).

结论:

  • 最佳的分泌物输送需要根据目标器官和治疗目标量身定制的系统.
  • 涂层,粘膜粘合剂和细胞粘合剂系统对于全身传递和预防新陈代谢至关重要.
  • 纳米封装和表面修饰增强了向肝脏和脏等特定器官的输送,改善了整体治疗结果.