神经细胞和天体细胞活动在响应移动的小鼠之间的解离
Anna Fedotova1,2, Alexey Brazhe1,2, Maxim Doronin2,3
1Faculty of Biology, Moscow State University, Moscow 119991, Russia.
Function (Oxford, England)
|June 21, 2023
概括
运动可以增加大脑细胞的活动. 天体细胞集成和放大信号,而神经元表现出即时反应,与天体细胞不同,在运动过程中表现出延迟和耐火动态.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 系统神经科学 系统神经科学
背景情况:
- 运动涉及复杂的神经回路.
- 星球细胞,质细胞,在大脑功能中起着至关重要的作用.
- 协调的神经元和神经细胞活动是大脑处理的基础.
研究的目的:
- 为了研究神经元和天体细胞在移动过程中的动态 (Ca2+) 反应.
- 为了比较天体细胞和神经元Ca2+信号的时间动态和折射性.
- 阐明天体细胞Ca2+整合和放大功能的含义.
主要方法:
- 在老鼠体感皮层中神经元和星体细胞的体内成像.
- 使用空运平台控制头部固定小鼠的运动.
- 分析Ca2+信号的传播,时间和响应模式,对重复的移动情节进行分析.
主要成果:
- 天体细胞Ca2+活动在移动过程中显著增加,起源于远端过程并传播到 soma.
- 天体细胞体作为Ca2+信号的集成器和放大器,表现出振荡行为.
- 神经元的Ca2+ ([Ca2+]i) 随着运动的开始迅速增加,而天体细胞信号则滞后数秒.
- 天体细胞显示出显著的折射性到第二次机动,不同于神经元.
结论:
- 运动期间的星细胞Ca2+信号与神经元信号不同,具有延迟和耐火性质.
- 天体细胞Ca2+动态可能涉及细胞内储存,有助于代谢和恒常支持.
- 这些发现突出了神经元和星细胞在处理与运动相关的大脑活动中的不同作用.
相关概念视频
01:12Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...