赫施普朗格病相关肠球炎:综合性综述
Eric M Gershon1, Leonel Rodriguez1, Ricardo A Arbizu2
1Section of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT 06520, United States.
World journal of clinical pediatrics
|June 21, 2023
概括
希尔什斯普朗格 (Hirschsprung) 是一个城市.
科学领域:
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
- 发展生物学 发展生物学
背景情况:
- 赫施普朗氏病 (HSCR) 是一种先天性疾病,由神经细胞迁移失败引起,导致远端肠道阻塞.
- 赫施普朗氏病相关肠球炎 (HAEC) 是HSCR的严重并发症,增加了患者的发病率和死亡率.
- 人们尚未完全了解HAEC的确切原因,但包括肠道动力不良,微生物失衡和肠道屏障功能减弱等因素.
研究的目的:
- 提供关于赫施普朗格病相关肠球炎 (HAEC) 的综合性综述.
- 阐明HAEC的临床表现,病因学和病理生理学.
- 总结目前用于管理HAEC的治疗策略.
主要方法:
- 对HAEC的临床表现,病因因素和病理生理机制的文献综述.
- 对HAEC的诊断标准和治疗指南的分析.
- 综合目前关于HAEC治疗选择的研究成果.
主要成果:
- HAEC呈现为HSCR的炎症并发症,发生在手术前或手术后.
- 导致HAEC病变的关键因素包括肠道动力不良,失生症和粘膜防御功能受损.
- 对HAEC的诊断主要是临床的,治疗是根据疾病严重程度量身定制的.
结论:
- 在HSCR管理中,HAEC是一个重要的临床挑战.
- 对HAEC病理生理学的进一步研究对于开发向疗法的发展至关重要.
- 需要对HAEC进行标准化定义和改进的治疗方案.
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