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K^trans 使用参考方法进行计算纠正原生T₁₀用于乳腺癌诊断

Pradeep Singh Negi^1,2, Shashi Bhushan Mehta^1,2, Amarnath Jena^1,2

¹PET Suite (Indraprastha Apollo Hospitals and House of Diagnostics), Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, New Delhi, India.

Journal of medical physics

|June 21, 2023

概括

使用幻影数据对T10值的空间校正显著提高了Ktrans在区分恶性和良性乳腺瘤的诊断准确性. 这种增强的表征有助于更精确的乳腺损伤分类.

关键词:

动态对比增强磁共振成像技术动态对比增强磁共振成像技术在 Ktrans Ktrans 中.在T1010中,使用的是T10.分子磁共振乳房线圈乳房线圈

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科学领域:

医疗成像医学成像
放射学放射学是指放射学
生物物理学的生物物理.

背景情况:

使用动态对比增强 (DCE) MRI 的乳腺病变的准确表征需要精确量化药物动力学参数,如Ktrans.
在T10值的空间变化可以在Ktrans计算中引入不准确性,可能会影响诊断性能.

研究的目的:

开发和验证一种方法来纠正乳房MRI中的空间T10值变化,使用幻影生成的校正因子.
评估T10校正对Ktrans诊断准确性的影响,用于将乳腺瘤分类为恶性或良性.

主要方法:

一个多管幻影被用来推导T10值的空间校正因子在一个4通道的乳房线圈内的不同位置.
这些校正因子被追溯应用到39名患者 (51个病变) 的DCE-MRI数据,这些病变是在同时使用PET/MRI系统获得的.
接收器操作特征 (ROC) 曲线分析是在经过校正和未经校正的Ktrans值上进行的.

主要成果:

T10值校正导致Ktrans平均值从0.60分钟-1提高到0.64分钟-1.1.
经过校正的数据,乳腺病变分类的诊断准确性显著提高:灵敏度增加到93.10%,特异性增加到86.36%,整体准确性增加到90.20%.
在ROC曲线下的面积 (AUC) 从0.824提高到0.959,表明更好的分类性能.

结论:

使用幻影衍生校正因子对T10值的规范化提高了Ktrans计算的可靠性.
经过校正的Ktrans值显示,诊断准确度显著提高,从而更好地表征和分类乳腺病变.