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使用开源3D染软件设计和模拟现实的空间频域成像系统.

Jane Crowley1, George S D Gordon1

  • 1Optics & Photonics Group, Department of Electrical and Electronic Engineering, University of Nottingham, Nottingham, United Kingdom.

Biomedical optics express
|June 21, 2023
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概括

一个新的基于Blender的模拟工具准确地模拟了各种几何形状的空间频域成像 (SFDI). 该系统增强了用于生物医学应用的SFDI系统设计和性能评估.

科学领域:

  • 生物医学光学 生物医学光学
  • 医疗成像医学成像
  • 计算成像技术的成像

背景情况:

  • 空间频域成像 (SFDI) 是绘制组织光学特性的一个有价值的技术,对于瘤等疾病的检测至关重要.
  • 现有的SFDI系统面临着各种成像几何学的挑战,需要先进的设计和模拟工具.
  • 现实的模拟对于优化SFDI系统在各种应用中的性能至关重要,从ex vivo样本到in vivo光线成像.

研究的目的:

  • 开发一个开源的空间频域成像 (SFDI) 模拟系统,使用Blender的3D建模和光线跟踪功能.
  • 为了实现对各种成像几何形状和样本类型的SFDI性能进行现实的模拟.
  • 加速设计和评估生物医学应用的新型SFDI系统.

主要方法:

  • 使用Blender's Cycles光线追踪引擎模拟各种几何形状的SFDI,结合现实的光学特性和照明效果.
  • 与蒙特卡洛方法对仿真准确度进行了验证,获得了吸收系数的16%和散射系数的18%的初始差异.
  • 实施经验推导的查找表,以显著降低模拟误差,使吸收率降低到1%和散射率降低到0.7%.

主要成果:

  • 证明了模拟瘤球体的吸收,散射和形状的准确SFDI映射,显示了增强的对比度.
  • 在管状光线内成功模拟了SFDI,揭示了针对不同纵向段的定制查找表的必要性.

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  • 在光度模拟中实现了高精度,吸收和散射系数的误差低至2%.

    • 结论:

    • 开发的基于Blender的模拟系统为设计和评估SFDI系统提供了强大而通用的工具.
    • 模拟方法准确地模拟复杂的几何和光学现象,提高SFDI性能预测的可靠性.
    • 预计该工具将在开发用于关键生物医学应用的先进SFDI技术方面发挥重要作用.