重症手术患者的抗血素III水平:它们与静脉动脉突发症相关吗?
Umar F Bhatti1, Navpreet K Dhillon2, Russell Mason1
1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Trauma surgery & acute care open
|June 21, 2023
概括
手术重症监护患者的低抗素III (ATIII) 水平与静脉血栓栓塞 (VTE) 风险增加,住院时间延长和死亡率增加相关. 创伤患者可能具有不同的静脉瘤风险概况.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 外科手术的结果
背景情况:
- 抗血素III (ATIII) 缺乏与静脉血栓塞栓症 (VTE) 风险的增加有关.
- 在危急病重症手术患者中,VTE是一个重大问题.
- 了解该人群中的ATIII水平对于风险分层至关重要.
研究的目的:
- 调查抗素III (ATIII) 水平与手术重症监护室 (SICU) 患者的静脉瘤发病率之间的关联.
- 评估ATIII水平对SICU患者停留时间 (LOS) 和死亡率的影响.
主要方法:
- 对2017年1月至2018年4月期间入院的227名SICU患者的回顾性分析.
- 患者根据抗血素III (ATIII) 水平 (低<80%与正常) 进行分类.
- 群体之间的VTE率,LOS和死亡率的比较;创伤患者的亚组分析.
主要成果:
- 66.9%的患者的ATIII水平较低.
- 较低的ATIII水平与显著更高的VTE率 (28.9%与16%,p=0.04) 相关.
- 低ATIII水平与长时间的LOS (76.3%与60%,p=0.01) 和增加的死亡率 (21.7%与6.7%,p<0.01) 相相关.
结论:
- 患有低抗血素III (ATIII) 水平的重症手术患者面临高风险的VTE,长时间住院,和更高的死亡率.
- 即使在正常的ATIII水平下,重症创伤患者也可能表现出高VTE发病率,这表明独特的病理生理机制.
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