80岁以上的老年患者接受结肠直肠癌切除术:开发和验证预测性生存名录的生存率
Aik Yong Chok1, Yun Zhao2,3, Hui Lionel Raphael Chen2
1Department of Colorectal Surgery, Singapore General Hospital, Singapore 169608, Singapore. chokaikyong@gmail.com.
World journal of gastrointestinal surgery
|June 21, 2023
概括
这项研究开发了一种名谱,用于预测80岁以上接受结肠直肠癌 (CRC) 手术的老年患者的生存率. 该工具准确地识别高风险患者,有助于结直肠癌的手术决策.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 结肠直肠癌 (CRC) 手术是局部疾病的主要治疗方法.
- 对于老年CRC患者 (>80岁) 的手术决策,需要准确的预测工具.
研究的目的:
- 开发和验证预测CRC切除的老年患者 (>80岁) 的整体存活率的诺米克图.
主要方法:
- 利用了295名老年CRC患者 (2018-2021) 的ACS-NSQIP数据库.
- 使用考克斯回归和LASSO回归选择的预后变量.
- 使用培训 (60%) 和验证 (40%) 队列,构建并验证了1年和3年生存的诺米克图.
主要成果:
- 诺莫格拉姆包括8个预测因素:年龄,并发症指数,BMI,白蛋白,转移,紧急手术和术后并发症 (肺炎,心脏病).
- 获得了高AUC值 (1年:0.843列车,0.826验证;3年:0.788列车,0.750验证).
- 证明了优秀的区分 (C指数:0.845列车,0.793验证) 和校准,风险组之间的生存差异显著 (P < 0.001).
结论:
- 一个经过验证的诺基基预测,在接受CRC切除的老年患者 (>80岁) 中,1年和3年的生存率.
- 诺米图支持对这个患者群体进行知情,整体的决策.
相关概念视频
Cancer Survival Analysis
402
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402
Comparing the Survival Analysis of Two or More Groups
228
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
228


