长期暴露于酒精会通过过度活跃的前运动性皮质干活动改变动作控制
Drew C Schreiner1, Andrew Wright1, Emily T Baltz2
1Department of Psychology, University of California San Diego, La Jolla, CA 92093, USA.
Cell reports
|June 21, 2023
概括
长期暴露于酒精会通过破坏前运动皮层电路来损害决策能力. 减少这些电路中的过度活动恢复了小鼠的目标导向动作控制,这表明AUD治疗的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
背景情况:
- 酒精使用障碍 (AUD) 影响决策和行动控制.
- 前运动性皮质三角管回路对于平衡目标导向和习惯性行为至关重要,并且与AUD有关.
研究的目的:
- 研究AUD中中断的前运动活动和改变的动作控制之间的因果关系.
- 探索前运动皮层 (M2) 到背部中间条纹体 (M2-DMS) 通道在酒精对决策的影响中的作用.
主要方法:
- 为了模拟AUD,小鼠被暴露在慢性间歇性乙醇 (CIE) 中.
- 在动作控制任务期间,成像评估了M2-DMS神经元中的神经活动.
- 化学遗传学用于减少M2-DMS通路中的神经元过活.
主要成果:
- 暴露于CIE损害了小鼠使用最近行动信息指导后续行动的能力.
- 长期暴露于酒精导致在动作控制期间M2-DMS神经元活动增加.
- 过度活跃的M2-DMS神经元的化学基因抑制挽救了目标导向的行动控制.
结论:
- 慢性酒精会破坏前运动回路功能,因果关系将异常的M2-DMS活动与AUD中受损的决策策略联系起来.
- 准前运动区域活动为AUD提供了潜在的治疗策略.
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