在异常性REM睡眠行为障碍中增加门中的自由水
Dongling Zhang1,2,3, Liche Zhou4, Junye Yao5
1Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
概括
自由水成像揭示了异常REM睡眠行为障碍患者背后膜的微观结构变化增加,表明早期帕金森症的可能性.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 运动障碍 运动障碍
背景情况:
- 帕金森氏病 (PD) 涉及低向性多巴胺基通路退化.
- 异常性REM睡眠行为障碍 (iRBD) 是一种前发性同核因子病变阶段.
- 早期的微观结构变化可能会在PD中发生神经元损失之前.
研究的目的:
- 在iRBD患者中使用自由水成像来评估dorsoposterior putamen (DPP) 的微结构变化.
- 评估自由水成像作为同核蛋白病变早期诊断标记物的潜力.
主要方法:
- 使用自由水成像来比较健康对照组 (n=48),iRBD患者 (n=43) 和PD患者 (n=47) 的DPP,背前膜 (DAP) 和后黑质体 (pSN).
- 在iRBD患者中,分析了自由水值与临床表现或多巴胺转运体 (DAT) 条状结合比率 (SBR) 之间的关系.
主要成果:
- 与对照组相比,iRBD和PD组的DPP和pSN中的自由水值显著更高.
- 在iRBD患者中,DPP自由水值在纵向上升,与临床进展和条状DAT SBR.相关.
- 基线DPP自由水与条状DATSBR和低血有负相关,与运动缺陷有正相关.
结论:
- 在DPP中增加的自由水值在协核蛋白病变的前进阶段在横截面和纵向观察到.
- DPP自由水成像与临床症状和多巴胺系统功能有关.
- 对DPP的自由水成像显示为早期诊断和监测同核蛋白病变进展的生物标志物具有前途.
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